{"id":27981,"date":"2020-01-21T18:45:15","date_gmt":"2020-01-21T16:45:15","guid":{"rendered":"https:\/\/www.alpha-cat.org\/cbd-v-zivote-zen\/"},"modified":"2025-12-14T20:36:25","modified_gmt":"2025-12-14T18:36:25","slug":"cbd-v-zivote-zen","status":"publish","type":"post","link":"https:\/\/www.alpha-cat.org\/cs\/cbd-v-zivote-zen\/","title":{"rendered":"CBD v \u017eivot\u011b \u017een"},"content":{"rendered":"Konop\u00ed se po tis\u00edcilet\u00ed ve v\u00fdchodn\u00ed medic\u00edn\u011b pou\u017e\u00edv\u00e1 k <strong>l\u00e9\u010db\u011b \u017eensk\u00fdch indispozic\u00ed<\/strong>; z\u00e1padn\u00ed medic\u00edna objevuje farmakologii kanabinoid\u016f; \u017eeny jsou citliv\u011bj\u0161\u00ed na konop\u00ed, n\u00e1chyln\u011bj\u0161\u00ed k jeho \u00fa\u010dink\u016fm, k\u00a0z\u00e1vislosti, zneu\u017e\u00edv\u00e1n\u00ed a relapsu. CBD v \u017eivot\u011b \u017een.\r\n\r\nTento sexu\u00e1ln\u00ed dimorfn\u00ed \u00fa\u010dinek souvis\u00ed se sekrec\u00ed estrogenu: <strong>gonad\u00e1ln\u00ed hormony a endokanabinoidn\u00ed syst\u00e9m (ECS) jsou \u00fazce propojeny.<\/strong>\r\n\r\nECS ovliv\u0148uje uvol\u0148ov\u00e1n\u00ed estrogen\u016f prost\u0159ednictv\u00edm regulace <strong>luteiniza\u010dn\u00edho hormonu (LH) a hormonu uvol\u0148uj\u00edc\u00edho gonadotropin (GnRH)<\/strong>; Exprese CB1R je modulov\u00e1na estradiolem a anandamid je vy\u0161\u0161\u00ed s ni\u017e\u0161\u00ed aktivitou amidhydroxyl\u00e1zy mastn\u00fdch kyselin (FAAH).\r\n\r\nAnandamid je <strong>vy\u0161\u0161\u00ed b\u011bhem folikul\u00e1rn\u00ed f\u00e1ze<\/strong> a nejvy\u0161\u0161\u00ed b\u011bhem ovulace a ni\u017e\u0161\u00ed v lute\u00e1ln\u00ed f\u00e1zi.\r\n\r\nECS hraje v\u00fdznamnou roli p\u0159i <strong>regulaci<\/strong> menstrua\u010dn\u00edho cyklu a plodnosti.\r\n<ul>\r\n \t<li>Estrogen je uklid\u0148uj\u00edc\u00ed anxiolytikum a antidepresivum pomoc\u00ed mechanismu ECS.<\/li>\r\n \t<li>Estrogen reguluje ECS, reguluje FAAH v d\u011bloze a imunitn\u00edch bu\u0148k\u00e1ch.<\/li>\r\n \t<li>Estrogenov\u00e9 a mozkov\u00e9 kanabinoidy jsou hlavn\u00edmi modul\u00e1tory afektu, emoc\u00ed, soci\u00e1ln\u00edho a sexu\u00e1ln\u00edho chov\u00e1n\u00ed.<\/li>\r\n \t<li>Estrogen moduluje produkci receptorov\u00e9 aktivity a degradaci endokanabinoid\u016f v centr\u00e1ln\u00edm nervov\u00e9m syst\u00e9mu a ECS reguluje produkci estrogenu sn\u00ed\u017een\u00edm uvol\u0148ov\u00e1n\u00ed gonadotropin\u016f.<\/li>\r\n<\/ul>\r\nEndokanabinoidy reguluj\u00ed uvol\u0148ov\u00e1n\u00ed neuropeptid\u016f, neurotransmiter\u016f a hladiny hypof\u00fdzy hypotalamu a gonad\u00e1ln\u00ed a nadledvinov\u00e9 hladiny.\r\n\r\n\u017deny mus\u00ed po cel\u00fd sv\u016fj \u017eivot sn\u00e1\u0161et <strong>ur\u010dit\u00e1 \u201ep\u0159irozen\u00e1 utrpen\u00ed\u201c.<\/strong>\r\n\r\n<strong>Kdy\u017e jsou dosp\u00edvaj\u00edc\u00ed d\u00edvky<\/strong>\r\n<ol>\r\n \t<li>zah\u00e1jen\u00ed menstrua\u010dn\u00ed dysmenorey je velmi \u010dast\u00e9 a obvykl\u00e1 l\u00e9\u010dba zahrnuje antispasmodick\u00e1 a NSAID l\u00e9\u010diva<\/li>\r\n \t<li>akn\u00e9 (chlapci a d\u00edvky) s produkc\u00ed mu\u017esk\u00fdch hormon\u016f<\/li>\r\n<\/ol>\r\n<em>Obvykle p\u0159edeps\u00e1no<\/em>\r\n<ul>\r\n \t<li>antibiotika absurdn\u011b p\u0159edepisovan\u00e1 na roky<\/li>\r\n \t<li>antiandrogen, cyproteron se z\u00e1va\u017en\u00fdmi vedlej\u0161\u00edmi \u00fa\u010dinky, jako jsou mozkov\u00e9 n\u00e1dory<\/li>\r\n \t<li>syntetick\u00e1 estroprogestativn\u00ed l\u00e9\u010diva s vedlej\u0161\u00edmi \u00fa\u010dinky, jako jsou krevn\u00ed sra\u017eeniny<\/li>\r\n \t<li>isotretinoin se z\u00e1va\u017en\u00fdmi vedlej\u0161\u00edmi \u00fa\u010dinky, jako je po\u0161kozen\u00ed jater<\/li>\r\n<\/ul>\r\n<strong>Kdy\u017e jsou dosp\u011bl\u00ed ve v\u011bku 20\u201350 let, hledaj\u00ed spole\u010dn\u00edka, vychov\u00e1vaj\u00ed d\u011bti, sna\u017e\u00ed se b\u00fdt efektivn\u00ed ve sv\u00e9 pr\u00e1ci a ovl\u00e1d\u00e1n\u00ed sv\u00e9 plodnosti.<\/strong>\r\n<ol>\r\n \t<li>Mohou trp\u011bt \u00fazkost\u00ed, emocemi, depres\u00ed, vyho\u0159en\u00edm<\/li>\r\n \t<li>Mohou m\u00edt poruchy imunity s\u00a0nedostate\u010dnou funkc\u00ed \u0161t\u00edtn\u00e9 \u017el\u00e1zy a nadledvin a chronick\u00fdmi infekcemi<\/li>\r\n \t<li>Kdy\u017e cht\u011bj\u00ed m\u00edt d\u00edt\u011b, m\u016f\u017ee to b\u00fdt obt\u00ed\u017en\u011bj\u0161\u00ed, proto\u017ee biologick\u00e9 hodiny jim sn\u00ed\u017eily potenci\u00e1l plodnosti<\/li>\r\n<\/ol>\r\nJejich cykly a menstruace mohou naru\u0161ovat menoragii s menstruac\u00ed. Fibromyalgie a endometri\u00f3za jsou ob\u00e1van\u00e9 choroby. Ka\u017ed\u00e9 t\u011bhotenstv\u00ed a porod jsou v\u00fdznamnou f\u00e1z\u00ed \u017eivota \u017eeny.\r\n\r\n<em>Jej\u00ed obvykl\u00e9 l\u00e9ky jsou<\/em>\r\n<ul>\r\n \t<li>or\u00e1ln\u00ed kontraceptiva s rizikem krevn\u00edch sra\u017eenin a rakoviny prsu<\/li>\r\n \t<li>pr\u00e1\u0161ky na span\u00ed, antidepresiva<\/li>\r\n<\/ul>\r\n<strong>Kdy\u017e p\u0159ijde menopauza, mus\u00ed d\u00e1ma st\u00e1le bojovat:<\/strong>\r\n<ol>\r\n \t<li>aby se zabr\u00e1nilo ob\u00e1van\u00e9mu riziku rakoviny<\/li>\r\n \t<li>kv\u016fli ochran\u011b sv\u00fdch kost\u00ed: l\u00e9\u010dba bisfosfon\u00e1ty p\u0159in\u00e1\u0161\u00ed riziko osteonekr\u00f3zy<\/li>\r\n \t<li>a chr\u00e1nit svoji k\u016f\u017ei, kr\u00e1su, libido<\/li>\r\n \t<li>chr\u00e1nit sv\u00e9 vzpom\u00ednky<\/li>\r\n \t<li>aby se zabr\u00e1nilo depresi a artritid\u011b<\/li>\r\n<\/ol>\r\nHormon\u00e1ln\u00ed substitu\u010dn\u00ed l\u00e9\u010dba (HRT), kter\u00e1 byla z velk\u00e9 \u010d\u00e1sti p\u0159edeps\u00e1na, <strong>nen\u00ed bezpe\u010dn\u00e1 \u2013 zvy\u0161uji \u0161anci na rakovinu prsu a vaje\u010dn\u00edk\u016f<\/strong>.\r\n\r\nZnepokojen\u00ed vyvol\u00e1v\u00e1 <strong>n\u00e1lo\u017e estrogen\u016f<\/strong> z antikoncep\u010dn\u00ed pilulky, xenoestrogeny z prost\u0159ed\u00ed a hormon\u00e1ln\u00ed substitu\u010dn\u00ed terapie a nedostatek jodu.\r\n\r\n<strong>L\u00e9ka\u0159sk\u00e9 konop\u00ed a CBD mohou b\u00fdt dal\u0161\u00edm paradigmatem l\u00e9\u010dby a mohou poskytnout bezpe\u010dn\u011bj\u0161\u00ed alternativu.<\/strong>\r\n\r\nKonop\u00ed m\u00e1 v gynekologii a porodnictv\u00ed dlouhou historii a m\u00e1 pov\u011bst, \u017ee um\u00ed \u00fa\u010dinn\u011b l\u00e9\u010dit dysmenoreu, menoragii, poruchy a mo\u010di. Poch\u00e1z\u00ed od britsk\u00fdch a americk\u00fdch l\u00e9ka\u0159\u016f v letech 1840-1940 a\u017e ke slavn\u00fdm arabsk\u00fdm a \u010d\u00ednsk\u00fdm v\u011bdc\u016fm minul\u00fdch stalet\u00ed a do Egypta a Sumeru.\r\n\r\nK posouzen\u00ed jejich \u00fa\u010dinnosti jsou samoz\u0159ejm\u011b nutn\u00e9 klinick\u00e9 studie, nicm\u00e9n\u011b ve srovn\u00e1n\u00ed se v\u0161emi z\u00e1va\u017en\u00fdmi vedlej\u0161\u00edmi \u00fa\u010dinky skute\u010dn\u00fdch l\u00e9\u010div a jejich omezenou \u00fa\u010dinnost\u00ed je t\u0159eba zv\u00e1\u017eit v\u0161e.\r\n<h2><strong>Kanabidiol (CBD)<\/strong><\/h2>\r\n<ol>\r\n \t<li>negativn\u00ed alosterick\u00fd modul\u00e1tor CB1R, GABAR<\/li>\r\n \t<li>\u010d\u00e1ste\u010dn\u00fd nep\u0159\u00edm\u00fd antagonista CB2R<\/li>\r\n \t<li>p\u016fsob\u00ed na 5HTR, VR1R, A2AR, GPR55 &amp; GPR18, TPVR, dopamin R, serotonin R<\/li>\r\n \t<li>zesiluje glycinov\u00fd receptor, blokuje TNF-alfa<\/li>\r\n \t<li>inhibuje rozklad anandamidu a 2-AG<\/li>\r\n \t<li>prodlu\u017euje \u00fa\u010dinky THC blokov\u00e1n\u00edm degraduj\u00edc\u00edch enzym\u016f, sni\u017euje intoxika\u010dn\u00ed \u00fa\u010dinky THC<\/li>\r\n<\/ol>\r\n<strong><u>Vlastnosti CBD:<\/u><\/strong>\r\n<ol>\r\n \t<li>neuroprotektant<\/li>\r\n \t<li>analgetikum<\/li>\r\n \t<li>stimul\u00e1tor chuti k j\u00eddlu<\/li>\r\n \t<li>antikonvulzivn\u00ed<\/li>\r\n \t<li>svalov\u00fd relaxant<\/li>\r\n \t<li>anxiolytick\u00fd<\/li>\r\n \t<li>antidepresivum<\/li>\r\n \t<li>podporuje r\u016fst kost\u00ed<\/li>\r\n \t<li>antibakteri\u00e1ln\u00ed<\/li>\r\n \t<li>protiz\u00e1n\u011btliv\u00fd<\/li>\r\n<\/ol>\r\n<strong><u>Hlavn\u00ed \u00fadaje o CBD:<\/u><\/strong>\r\n<ol>\r\n \t<li>kontrola epilepsie<\/li>\r\n \t<li>spasticita a bolest z roztrou\u0161en\u00e9 skler\u00f3zy<\/li>\r\n \t<li>kontrola bolesti u artritidy, rakovina<\/li>\r\n \t<li>\u00fazkost, deprese<\/li>\r\n \t<li>nespavost<\/li>\r\n \t<li>z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed: revmatoidn\u00ed artritida, syndrom dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku, metabolick\u00e1 onemocn\u011bn\u00ed diabetes<\/li>\r\n \t<li>protin\u00e1dorov\u00e1 aktivita, rakovina mozku, prsu, endometria<\/li>\r\n \t<li>poruchy endometri\u00f3zy bun\u011b\u010dn\u00e9 migrace; lup\u00e9nka<\/li>\r\n \t<li>podporuje osteopor\u00f3zu r\u016fstu kost\u00ed, hojen\u00ed ran<\/li>\r\n \t<li>sn\u00ed\u017een\u00ed rizika mrtvice, stimuluje koron\u00e1rn\u00ed pr\u016ftok krve<\/li>\r\n \t<li>z\u00e1vislost na opioidech a pomoc p\u0159i z\u00e1vislosti na tab\u00e1ku a alkoholu<\/li>\r\n \t<li>ztr\u00e1ta pam\u011bti<\/li>\r\n \t<li>nevolnost a zvracen\u00ed<\/li>\r\n \t<li>inhibuje lipidy v sebocytech, l\u00e9\u010dba akn\u00e9<\/li>\r\n \t<li>dysmenorea a menoragie<\/li>\r\n<\/ol>\r\n<h2><strong>CBD PRO DOSP\u00cdVAJ\u00cdC\u00cd D\u00cdVKY<\/strong><\/h2>\r\n<strong>Prim\u00e1rn\u00ed dysmenorea je zp\u016fsobena k\u0159e\u010demi d\u011blohy.<\/strong>\r\n\r\nL\u00e9ka\u0159sk\u00e1 marihuana byla p\u0159edepisov\u00e1na na <strong>menoragii a dysmenoreu<\/strong> od starov\u011bku a na za\u010d\u00e1tku 20. stolet\u00ed britsk\u00fdmi a americk\u00fdmi l\u00e9ka\u0159i.\r\n<ul>\r\n \t<li><strong>dysmenorea<\/strong><\/li>\r\n<\/ul>\r\n<em>Sublingv\u00e1ln\u00ed CBD kapky 2,5%, 3%, 4%-5% po\u010d\u00ednaje 2 dny p\u0159ed menstruac\u00ed a, je-li to nutn\u00e9, \u010d\u00edpky a mas\u00e1\u017e p\u00e1nevn\u00ed oblasti relaxa\u010dn\u00edm antispasmodick\u00fdm kr\u00e9mem na b\u00e1zi CBD spojen\u00fdm se s\u00edranem ho\u0159e\u010dnat\u00fdm.<\/em>\r\n\r\nTo tak\u00e9 pom\u016f\u017ee zm\u00edrnit bolesti hlavy.\r\n\r\n\u017d\u00e1dn\u00e9 dal\u0161\u00ed NSAID ani peror\u00e1ln\u00ed antikoncepce nen\u00ed pot\u0159eba.\r\n<ul>\r\n \t<li><strong>akn\u00e9<\/strong><\/li>\r\n<\/ul>\r\n<em>Pro t\u011b\u017ek\u00e9 akn\u00e9 CBD kapky nebo tobolky 3%, 4 % 2-5 kapek\/den.<\/em>\r\n\r\n<em>CBD 3%, 4% p\u0159\u00edmo na l\u00e9ze.<\/em>\r\n<h2><strong>CBD pro dosp\u011bl\u00e9 \u017eeny<\/strong><\/h2>\r\n<strong>V\u0161ichni \u017eijeme ve sv\u011bt\u011b pln\u00e9m environment\u00e1ln\u00edch toxick\u00fdch expozic<\/strong> a \u017eeny v z\u00e1vislosti na jejich \u017eivotn\u00edm stylu, od stravy po kr\u00e1su, jsou pln\u011b vystaveny mnoha endokrinn\u00edm disruptor\u016fm. Peror\u00e1ln\u00ed antikoncep\u010dn\u00ed prost\u0159edky intrauterinn\u00ed za\u0159\u00edzen\u00ed a xenoestrogeny tuto z\u00e1t\u011b\u017e zvy\u0161uj\u00ed a jejich kapacity pro reprodukci, kontrolu emoc\u00ed a imunitu nemus\u00ed b\u00fdt optim\u00e1ln\u00ed.\r\n\r\nHormon\u00e1ln\u00ed nerovnov\u00e1ha mezi estradiolov\u00fdm progesteronem a mu\u017esk\u00fdmi hormony m\u00e1 mnoho p\u0159\u00edznak\u016f:\r\n<ul>\r\n \t<li><strong>poruchy v cyklech: premenstrua\u010dn\u00ed syndrom se zm\u011bnami n\u00e1lady, bolesti hlavy, menstrua\u010dn\u00ed k\u0159e\u010de, citlivost prsu, pot\u00ed\u017ee se sp\u00e1nkem, bolest zad, \u017eiln\u00ed nedostate\u010dnost.<\/strong><\/li>\r\n<\/ul>\r\nP\u0159\u00ed\u010dinami sekund\u00e1rn\u00ed dysmenorey jsou z\u00e1n\u011bt nebo infekce p\u00e1nve, endometri\u00f3za, adenomy\u00f3za, d\u011blo\u017en\u00ed myomy.\r\n\r\n<em>CBD sublingv\u00e1ln\u00ed 5% 5-10 mg\/den p\u0159ed span\u00edm.<\/em>\r\n\r\n<em>CBD olej 3% na prsa, na p\u00e1nevn\u00ed oblast.<\/em>\r\n<ul>\r\n \t<li><strong>emoce, \u00fazkost a deprese spojen\u00e9 s bolestmi hlavy, poruchy sp\u00e1nku, m\u00e9n\u011b libida zp\u016fsoben\u00e9 stresov\u00fdmi hormony jsou \u010dasto dan\u00ed \u00fasp\u011bchu v pr\u00e1ci<\/strong><\/li>\r\n<\/ul>\r\n<em>CBD sublingv\u00e1ln\u00ed 5%-10%, 10-50 mg\/den, den a noc.<\/em>\r\n\r\n<em>Rekt\u00e1ln\u00ed a vagin\u00e1ln\u00ed \u010d\u00edpky.<\/em>\r\n\r\n<em>CBD kr\u00e9m pro p\u00e1nevn\u00ed mas\u00e1\u017e.<\/em>\r\n\r\n<em>Lubrika\u010dn\u00ed gel s CBD.<\/em>\r\n\r\n<strong>\u017deny mohou pot\u0159ebovat r\u016fzn\u00e9 d\u00e1vky CBD v z\u00e1vislosti na r\u016fzn\u00fdch f\u00e1z\u00edch jejich cyklu.<\/strong>\r\n\r\nCelo\u017eivotn\u00ed expozice estrogenu neexponovan\u00e1 progesteronem zvy\u0161uje chronick\u00fd z\u00e1n\u011bt, z\u00e1n\u011bt p\u00e1nve, myomy d\u011blohy, r\u016fst rakoviny prsu a endotelu.\r\n\r\nRakovina prsu a rakovina endometria jsou z\u00e1visl\u00e9 na hormonech <strong>a CB2R zde hraje roli<\/strong>.\r\n\r\nCBD indukuje bun\u011b\u010dnou smrt bun\u011bk <strong>pozitivn\u00edch na estrogenov\u00fd receptor<\/strong> a bun\u011bk karcinomu prsu negativn\u00edch na estrogenov\u00fd receptor.\r\n<h2><strong><u>CBD a endometri\u00f3za<\/u><\/strong><\/h2>\r\nU endometri\u00f3zy a adenomy\u00f3zy je <strong>sn\u00ed\u017een\u00e1 exprese<\/strong> kanabinoidu CB1R a CB2R; pro n\u011bkter\u00e9 v\u011bdce je endometri\u00f3za klinick\u00fdm deficitem endokanabinoid\u016f.\r\n\r\nAbnorm\u00e1ln\u00ed r\u016fst endometria a perifern\u00ed inervace zp\u016fsobuje dysmenoreu, dyspareunii a riziko neplodnosti.\r\n\r\n<em>Kapky nebo tobolky CBD 10\u201330 mg\/den.<\/em>\r\n\r\n<em>\u010c\u00edpky CBD, ovule.<\/em>\r\n\r\n<em>CBD kr\u00e9m pro mas\u00e1\u017e.<\/em>\r\n<h2><strong><u>CBD a v\u00fdh\u0159ez genit\u00e1li\u00ed<\/u><\/strong><\/h2>\r\nZtr\u00e1ta p\u00e1nevn\u00ed podpory vede k sestupu <strong>p\u00e1nevn\u00edch org\u00e1n\u016f<\/strong>.\r\n\r\nVe f\u00e1zi menopauzy m\u016f\u017ee b\u00fdt nedostatek lok\u00e1ln\u00edho endokanabinoidn\u00edho syst\u00e9mu a porucha metabolismu kolagenu.\r\n\r\n<em>CBD kapky nebo tobolky 4%, 5% 5-10 mg\/den.<\/em>\r\n\r\n<em>Ovule a tampony CBD pom\u00e1haj\u00ed zvy\u0161ovat svalov\u00fd tonus fyzioterapi\u00ed p\u0159ed a po operaci.<\/em>\r\n\r\n<em>Sublingv\u00e1ln\u00ed CBD 4%, 5% pro zm\u00edrn\u011bn\u00ed stresu, lep\u0161\u00ed sp\u00e1nek a zabr\u00e1n\u011bn\u00ed migr\u00e9n\u00e1m.<\/em>\r\n\r\n<em>Sublingv\u00e1ln\u00ed CBD 10% pro zlep\u0161en\u00ed energie, lep\u0161\u00ed odolnost, zlep\u0161en\u00ed.<\/em>\r\n\r\n<strong>Lok\u00e1ln\u00ed CBD<\/strong>\r\n<ol>\r\n \t<li>ovule na k\u0159e\u010de<\/li>\r\n \t<li>\u010d\u00edpky, tr\u00e1vic\u00ed probl\u00e9my<\/li>\r\n \t<li>kr\u00e9my na artritidu, vaskul\u00e1rn\u00ed dilataci, \u017eiln\u00ed nedostate\u010dnost<\/li>\r\n \t<li>kosmetick\u00e9 kr\u00e9my na lup\u00e9nku<\/li>\r\n \t<li>lubrika\u010dn\u00ed gely<\/li>\r\n<\/ol>\r\n<h2><strong><u>CBD a t\u011bhotenstv\u00ed<\/u><\/strong><\/h2>\r\n<strong>ECS je \u017eivotn\u011b d\u016fle\u017eit\u00fd pro plodnost. <\/strong>Ve vaje\u010dn\u00edc\u00edch a d\u011bloze jsou komponenty ECS.\r\n\r\nN\u00edzk\u00e9 hladiny anandamidu (AEA) pro implantaci a t\u011bhotenstv\u00ed; zv\u00fd\u0161en\u00e1 hladina AEA nebo agonisty m\u016f\u017ee zp\u016fsobit vy\u0161\u0161\u00ed riziko potratu.\r\n\r\nVysok\u00e1 \u00farove\u0148 AEA usnad\u0148uje pracovn\u00ed proces.\r\n\r\nJe t\u0159eba vyhodnotit rizika spojen\u00e1 s v\u00fdvojem plodu a mozkem novorozenc\u016f.\r\n\r\n<em>Neexistuje dostatek klinick\u00fdch studi\u00ed, z \u010deho\u017e vypl\u00fdv\u00e1, \u017ee CBD se pro preventivn\u00ed opat\u0159en\u00ed nedoporu\u010duje t\u011bhotn\u00fdm a koj\u00edc\u00edm \u017een\u00e1m, nicm\u00e9n\u011b mnoho zku\u0161en\u00fdch l\u00e9ka\u0159\u016f na po\u010d\u00e1tku 19. stolet\u00ed ocenilo \u00fa\u010dinnost konop\u00ed na bolest b\u011bhem porodu a krv\u00e1cen\u00ed souvisej\u00edc\u00ed s porodem.<\/em>\r\n\r\nRakovina prsu, endometria, vaje\u010dn\u00edk\u016f s CBD a hormonem.\r\n\r\n<strong><u>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hormon\u00e1ln\u00ed l\u00e9ky pro \u017eeny a CYP<\/u><\/strong>\r\n\r\n<strong><u>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 CBD a peror\u00e1ln\u00ed antikoncep\u010dn\u00ed prost\u0159edky<\/u><\/strong>\r\n\r\nSubstr\u00e1ty CYP1A2: estradiol, ethinylestradiol\r\n\r\nSubstr\u00e1ty CYP2C9: testosteron\r\n\r\nSubstr\u00e1ty CYP2C19: progesteron\r\n\r\nSubstr\u00e1ty CYP2D6: tamoxifen\r\n\r\nSubstr\u00e1ty CYP3A4: ethinylestradiol, desogestrel, estradiol, progesteron, testosteron, hydrokortizon, medroxyprogesteron, norethisteron\r\n\r\nPeror\u00e1ln\u00ed antikoncep\u010dn\u00ed prost\u0159edky jsou substr\u00e1ty a inhibitory CYP1A2 a 3A4\r\n\r\nSyntetick\u00e9 progesterony progestin\u016f jsou substr\u00e1ty CYP3A4\r\n\r\nAntikoncep\u010dn\u00ed desogestrel progestin je substr\u00e1tem CYP3A4\r\n\r\n<strong>Proto\u017ee CBD inhibuje CYP2C9,2C19,3A4, s\u00e9rov\u00e9 hladiny t\u011bchto hormon\u016f se proto budou zvy\u0161ovat s vy\u0161\u0161\u00ed \u00farovn\u00ed souvisej\u00edc\u00edch rizik krevn\u00ed sra\u017eeniny a rakoviny.<\/strong>\r\n\r\n\u017dena, kter\u00e1 kou\u0159\u00ed tab\u00e1k, u\u017e\u00edv\u00e1 antikoncep\u010dn\u00ed pilulky, vypije p\u00e1r sklenic v\u00edna a u\u017e\u00edv\u00e1 CBD si mus\u00ed b\u00fdt v\u011bdoma nebezpe\u010d\u00ed tohoto mixu.\r\n\r\n<strong>Hormon\u00e1ln\u00ed substitu\u010dn\u00ed terapie je:<\/strong>\r\n\r\nEstradiol v subkut\u00e1nn\u00edch n\u00e1plastech a progesteronu\r\n\r\nMu\u017esk\u00e9 hormony DHEA a testosteron\r\n\r\n<strong>Konven\u010dn\u00ed l\u00e9\u010dba hormon\u00e1ln\u00ed substitu\u010dn\u00ed terapi\u00ed se uk\u00e1zala jako nebezpe\u010dn\u00e1 s n\u00e1r\u016fstem rakovin prsu a vaje\u010dn\u00edk\u016f.<\/strong>\r\n\r\n\u017deny po hormon\u00e1ln\u00ed substitu\u010dn\u00ed terapii ve form\u011b pilulek by si m\u011bly b\u00fdt v\u011bdomy nebezpe\u010d\u00ed, kter\u00e9 by mohlo nastat p\u0159i inhibici CYP inhibuj\u00edc\u00ed CBD, a m\u011bly by informovat sv\u00e9 l\u00e9ka\u0159e a po\u017e\u00e1dat o zm\u011bnu.\r\n\r\nTamoxifen, kter\u00fd je selektivn\u00edm modul\u00e1torem estrogenov\u00e9ho receptoru (SERM), je substr\u00e1tem CYP2D6 a 3A4 a prol\u00e9\u010divem, kter\u00e9 mus\u00ed b\u00fdt po degradaci transformov\u00e1no, aby byl aktivn\u00ed; s CBD inhibuj\u00edc\u00ed CYP2D6 a 3A4 tamoxifen z\u016fstane d\u00e9le v s\u00e9ru a degradace bude zpo\u017ed\u011bna, tak\u017ee bude m\u00e9n\u011b aktivn\u00ed formy tamoxifenu, tak\u017ee bude sn\u00ed\u017eena aktivita a \u00fa\u010dinnost bude men\u0161\u00ed.\r\n\r\n<strong>Rakoviny s CBD a hormonem (prsa, endometrium, vaje\u010dn\u00edky).<\/strong>\r\n\r\nCBD m\u00e1 protin\u00e1dorovou aktivitu a m\u016f\u017ee m\u00edt indikace k t\u011bmto patologi\u00edm krom\u011b \u010din\u016f pro celkov\u00e9 zdrav\u00ed t\u011bchto pacient\u016f.\r\n\r\n<strong>Doporu\u010duje se p\u0159idat CBG, kter\u00fd je ve vysok\u00fdch d\u00e1vk\u00e1ch pro karcinom prsu cytotoxick\u00fd.<\/strong>\r\n<h2><strong>Menopauza<\/strong><\/h2>\r\nVaje\u010dn\u00edky jsou v klidu.\r\n\r\nJe p\u0159\u00edtomen deficit estrogenu se sn\u00ed\u017een\u00edm signalizace ECS.\r\n\r\n\u010casn\u00e1 menopauza m\u016f\u017ee b\u00fdt klinick\u00fdm nedostatkem ECS.\r\n<ol>\r\n \t<li>n\u00e1valy horka, \u00fazkost, zm\u011bny n\u00e1lady, \u0161patn\u00fd sp\u00e1nek, p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze<\/li>\r\n \t<li>such\u00e1 k\u016f\u017ee, sliznice<\/li>\r\n \t<li>n\u00edzk\u00e9 libido<\/li>\r\n \t<li>ztr\u00e1ta hustoty kost\u00ed<\/li>\r\n \t<li>ztr\u00e1ta pam\u011bti<\/li>\r\n \t<li>deprese<\/li>\r\n \t<li>bolest<\/li>\r\n<\/ol>\r\n<strong>CBD m\u016f\u017ee nab\u00eddnout \u00falevu pro v\u0161echny stavy, kter\u00fdmi trp\u00ed st\u00e1rnouc\u00ed d\u00e1my.<\/strong>\r\n\r\nCBD pro srde\u010dn\u00ed a c\u00e9vn\u00ed nap\u011bt\u00ed, krevn\u00ed tlak, sn\u00ed\u017een\u00ed rizika mrtvice.\r\n\r\nCBD spojen\u00e1 s vitam\u00ednem D pro zdrav\u00ed kost\u00ed, k\u0159ehk\u00e9 kosti a rizika zlomenin.\r\n\r\nLektvar l\u00e1sky s CBD zvy\u0161uje touhu, pot\u011b\u0161en\u00ed, sexu\u00e1ln\u00ed chov\u00e1n\u00ed.\r\n\r\nCBD pro artritidu.\r\n\r\nCBD pro nespavost, deprese.\r\n\r\nCBD pro z\u00e1branu ztr\u00e1ty pam\u011bti.\r\n\r\n<em>Sublingv\u00e1ln\u00ed CBD 4%, 5%, 10%.<\/em>\r\n\r\n<em>Je\u0161t\u011b nen\u00ed dostupn\u00fd v mnoha zem\u00edch; jejich spot\u0159eba nebude vyvol\u00e1vat obavy jako u THC, proto\u017ee 7-COOH-CBD nen\u00ed psychoaktivn\u00ed.<\/em>\r\n\r\n<em>D\u00e1vky mohou dos\u00e1hnout 50-100 mg\/den.<\/em>\r\n\r\n<em>Aktu\u00e1ln\u00ed CBD pro bolest, pro p\u00e9\u010di a kr\u00e1su.<\/em>\r\n\r\n<em>Lubrikanty.<\/em>\r\n\r\n<em>Koupel s CBD.<\/em>\r\n<h2><strong>SHRNUT\u00cd<\/strong><\/h2>\r\n<strong>Souhra mezi osami ECS Hypothalamus Pituitary Gonad (HPG) a Hypothalamus Pituitary Adrenal (HPA) je rozs\u00e1hl\u00e1 a ovliv\u0148uje du\u0161evn\u00ed zdrav\u00ed a pohodu \u017een.<\/strong>\r\n\r\n<strong>\u017deny mus\u00ed b\u00fdt vzd\u011bl\u00e1v\u00e1ny, aby se mohly rozhodovat o zdrav\u00e9m zp\u016fsobu \u017eivota a u\u017e\u00edv\u00e1n\u00ed konop\u00ed.<\/strong>\r\n\r\n<strong>Konop\u00ed a jej\u00ed slo\u017eky, zejm\u00e9na CBD, poskytuj\u00ed \u017een\u00e1m mnoho v\u00fdhod b\u011bhem nejd\u016fle\u017eit\u011bj\u0161\u00edch epizod jejich \u017eivota v kr\u00e1tkodob\u00e9m i dlouhodob\u00e9m horizontu bez hrozby ubl\u00ed\u017een\u00ed.<\/strong>\r\n\r\n\u010cl\u00e1nek je napsan\u00fd <strong>Dr. Janine GASTON-NHAN<\/strong>. \u010cl\u00e1nek je form\u00e1tovan\u00fd a publikovan\u00fd od <a href=\"https:\/\/www.alpha-cat.org\/\">Alpha-Cat<\/a>.","protected":false},"excerpt":{"rendered":"<p>Konop\u00ed se po tis\u00edcilet\u00ed ve v\u00fdchodn\u00ed medic\u00edn\u011b pou\u017e\u00edv\u00e1 k l\u00e9\u010db\u011b \u017eensk\u00fdch indispozic\u00ed; z\u00e1padn\u00ed medic\u00edna objevuje farmakologii kanabinoid\u016f; \u017eeny jsou citliv\u011bj\u0161\u00ed na konop\u00ed, n\u00e1chyln\u011bj\u0161\u00ed k jeho \u00fa\u010dink\u016fm, k\u00a0z\u00e1vislosti, zneu\u017e\u00edv\u00e1n\u00ed a relapsu. CBD v \u017eivot\u011b \u017een. Tento sexu\u00e1ln\u00ed dimorfn\u00ed \u00fa\u010dinek souvis\u00ed se sekrec\u00ed estrogenu: gonad\u00e1ln\u00ed hormony a endokanabinoidn\u00ed syst\u00e9m (ECS) jsou \u00fazce propojeny. 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