{"id":27998,"date":"2020-01-21T19:12:52","date_gmt":"2020-01-21T17:12:52","guid":{"rendered":"https:\/\/www.alpha-cat.org\/?p=27998"},"modified":"2025-12-14T20:36:20","modified_gmt":"2025-12-14T18:36:20","slug":"francouzsky-lekar-nam-vysvetluje-endo-kanabinoidni-system","status":"publish","type":"post","link":"https:\/\/www.alpha-cat.org\/cs\/francouzsky-lekar-nam-vysvetluje-endo-kanabinoidni-system\/","title":{"rendered":"Francouzsk\u00fd l\u00e9ka\u0159 n\u00e1m vysv\u011btluje endo-kanabinoidn\u00ed syst\u00e9m"},"content":{"rendered":"\r\n<p><strong>Endokanabinoidn\u00ed syst\u00e9m (ECS)<\/strong> byl objeven asi p\u0159ed dvaceti lety po objevu <strong>\u03949 tetrahydrokanabinolu (THC)<\/strong>, jeho synt\u00e9ze a specifick\u00e9m zp\u016fsobu p\u016fsoben\u00ed (psychoaktivita) (Mechoulam 1964), objevu kanabinoidn\u00edch <strong>receptor\u016f CB1 (Howlett 1986) a CB2 (Munro 1993)<\/strong> a identifikaci 2 ligand\u016f Anandamidu (AEA Devane 1992) a 2-arachydonylglycerolu (2-AG Mechoulam 1995). Je to \u0161irok\u00e1 s\u00ed\u0165 <strong>mezibun\u011b\u010dn\u00e9 komunikace<\/strong> nezbytn\u00e1 pro udr\u017een\u00ed stabiln\u00edho vnit\u0159n\u00edho prost\u0159ed\u00ed: HOMEOST\u00c1ZE; Biologick\u00e1 harmonie, i kdy\u017e ve vn\u011bj\u0161\u00edm prost\u0159ed\u00ed mohou kol\u00edsat zne\u010di\u0161t\u011bn\u00ed, \u017eivotn\u00ed styl, \u0161patn\u00e1 strava nebo genetick\u00e9 variace nebo epigenetika. Tento <strong>neuromodula\u010dn\u00ed v\u0161udyp\u0159\u00edtomn\u00fd syst\u00e9m<\/strong>, \u0161iroce vyj\u00e1d\u0159en\u00fd existenc\u00ed kanabinoidn\u00edch receptor\u016f na ka\u017ed\u00e9 tk\u00e1ni a ka\u017ed\u00e9 bu\u0148ce <strong>v\u0161ech biologick\u00fdch syst\u00e9m\u016f, ovl\u00e1d\u00e1 fyziologickou rovnov\u00e1hu pro kontrolu t\u011blesn\u00e9 teploty, sp\u00e1nku, p\u0159\u00edjmu potravy, t\u011blesn\u00e9 hmotnosti, bolesti, pam\u011bti, u\u010den\u00ed, n\u00e1lady, emo\u010dn\u00ed regulace, motivace, odm\u011bny a z\u00e1vislosti, plodnosti, reprodukce, pre-a postnat\u00e1ln\u00edho v\u00fdvoje a motility.<\/strong> <a href=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-scaled.jpg\"><img fetchpriority=\"high\" decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-scaled.jpg\" class=\"aligncenter  wp-image-16217 lazyload\" alt=\"French doctor explains us endo-cannabinoid system\" width=\"803\" height=\"719\"><noscript><img decoding=\"async\" class=\"aligncenter  wp-image-16217\" src=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-scaled.jpg\" alt=\"French doctor explains us endo-cannabinoid system\" width=\"803\" height=\"719\" srcset=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-scaled.jpg 1600w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-scaled-600x537.jpg 600w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-scaled-1000x896.jpg 1000w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-300x269.jpg 300w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-1024x917.jpg 1024w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-768x688.jpg 768w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-1536x1376.jpg 1536w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-2048x1834.jpg 2048w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-scaled-500x448.jpg 500w\" sizes=\"(max-width: 803px) 100vw, 803px\" \/><\/noscript><\/a> V p\u0159\u00edpad\u011b naru\u0161en\u00ed bun\u011b\u010dn\u00e9 homeost\u00e1zy <strong>je ECS aktivov\u00e1n<\/strong> zp\u016fsobem specifick\u00fdm pro ligand-receptor pro prostor a \u010das. <strong>ECS je p\u0159\u00edtomen ve v\u0161ech obratlovc\u00edch \u2013 u lid\u00ed od velmi ran\u00e9ho st\u00e1dia embryogeneze.<\/strong> ECS zahrnuje: <strong>2 endokanabinoidn\u00ed ligandy 1) AEA a 2) 2-AG, lipidov\u00e9 slou\u010deniny jsou syntetizovan\u00ed retrogr\u00e1dn\u00ed poslov\u00e9.<\/strong><\/p>\r\n<ul>\r\n<li>A) na vy\u017e\u00e1d\u00e1n\u00ed B) kdy\u017e C) tam, kde jsou pot\u0159eba a rychle degradov\u00e1ny; p\u016fsob\u00ed na presynaptick\u00fd neuron pro modulaci uvol\u0148ov\u00e1n\u00ed neurotransmiter\u016f, zat\u00edmco neurotransmitery a hormony jsou ulo\u017eeny.<\/li>\r\n<li>AEA je \u010d\u00e1ste\u010dn\u00fd agonista na CB1R a CB2R, ovliv\u0148uje pam\u011b\u0165 a z\u00e1nik \u0161patn\u00fdch vzpom\u00ednek (posttraumatick\u00e1 stresov\u00e1 porucha), emoce, odm\u011bnu, z\u00e1vislost, analgezii, implantaci embrya, inhibici bun\u011b\u010dn\u00e9 proliferace, indukci apopt\u00f3zy.<\/li>\r\n<li>2-AG nejhojn\u011bj\u0161\u00ed, je pln\u00fd agonista pro CB1R a CB2R, reguluje p\u0159\u00edjem potravy, energetick\u00fd metabolismus, n\u00e1ladu, sexu\u00e1ln\u00ed chov\u00e1n\u00ed, \u00fazkostnou depresi, z\u00e1vislost, z\u00e1n\u011btliv\u00e9, neuroz\u00e1n\u011btliv\u00e9 procesy, imunitn\u00ed reakce, proz\u00e1n\u011btliv\u00e9 medi\u00e1tory po poran\u011bn\u00ed, kontrolu bolesti a ur\u010dit\u00e9 typy proliferace rakovinn\u00fdch bun\u011bk.<\/li>\r\n<\/ul>\r\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-2-510x405.jpg\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-2-510x405.jpg\" class=\"aligncenter  wp-image-16221 lazyload\" alt=\"\" width=\"763\" height=\"606\"><noscript><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter  wp-image-16221\" src=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-2-510x405.jpg\" alt=\"\" width=\"763\" height=\"606\" srcset=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-2-510x405.jpg 510w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-2-510x405-500x397.jpg 500w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-2-510x405-300x238.jpg 300w\" sizes=\"(max-width: 763px) 100vw, 763px\" \/><\/noscript><\/a><\/p>\r\n<div class=\"mceTemp\">\u00a0<\/div>\r\n<p><strong>Receptory um\u00edst\u011bn\u00e9 v bun\u011b\u010dn\u00e9 membr\u00e1n\u011b informuj\u00ed bu\u0148ky; receptor je protein, kter\u00fd interaguje s l\u00e1tkami mimo bu\u0148ku a vytv\u00e1\u0159\u00ed odpov\u011b\u010f v bu\u0148ce.<\/strong><\/p>\r\n<ul>\r\n<li>CB1R pro regulaci t\u011blesn\u00e9 teploty, rovnov\u00e1hy tekutin, pocen\u00ed, chuti k j\u00eddlu, koncentrace iont\u016f, hladin cukru, um\u00edst\u011bn\u00fdch ++++ v baz\u00e1ln\u00edch gangli\u00edch (motorick\u00e1 aktivita), hippocampu (pam\u011b\u0165) susbstantia nigra (pohyb), rhombencephale (analg\u00e9zie), cerebellu, (rovnov\u00e1ha ch\u016fze) \u010dichu (v\u016fn\u011b) + mozkov\u00e1 k\u016fra, septum, amygdala (emoce), hypotalamus, neurony astrocyty oligodendrocyty; tato vysok\u00e1 hustota vede k v\u00fdrazn\u00e9 mozkov\u00e9 a psychoaktivn\u00ed expresi v\u00a0o\u010d\u00edch, perifern\u00edch org\u00e1nech, srdci, d\u00fdchac\u00edch cest\u00e1ch, za\u017e\u00edvac\u00edm traktu, reproduk\u010dn\u00edch syst\u00e9mech, ledvin\u00e1ch, svalech, k\u016f\u017ei.<\/li>\r\n<li>CB2R pro regulaci imunitn\u00edch odpov\u011bd\u00ed, z\u00e1n\u011bt\u016f, bun\u011b\u010dn\u00e9 migrace, apopt\u00f3zy, hustoty kost\u00ed, nov\u00e9 produkce tk\u00e1n\u011b, potla\u010dov\u00e1n\u00ed bolesti +++ v mikrogli\u00edch, astrocytech neuron\u016f, mandl\u00ed, brzl\u00edku, sleziny, bu\u0148k\u00e1ch imunitn\u00edho syst\u00e9mu (makrof\u00e1gy, lymfocyty B a T, monocyty, \u017e\u00edrn\u00e9 bu\u0148ky), k\u016f\u017ei.<\/li>\r\n<li>Dal\u0161\u00ed zapojen\u00e9 receptory: GABA TRPV1, GPR 55, PPAR.<\/li>\r\n<li>Na v\u0161ech t\u011bchto receptorech mohou b\u00fdt ligandy AEA, 2-AG a fytokanabinoidy THC a kanabidiol (CBD) CBG, CBN, CBC, THCV agonisty \u010d\u00e1ste\u010dn\u00fdmi agonisty, pln\u00fdmi agonisty, inverzn\u00ed agonisty\u2026 alosterick\u00fdmi modul\u00e1tory pozitivn\u00edmi a negativn\u00edmi, \u010d\u00edm\u017e se m\u011bn\u00ed exprese receptor\u016f.<\/li>\r\n<\/ul>\r\n<p><strong>Enzymy odpov\u011bdn\u00e9 za synt\u00e9zu a degradaci endokanabinoid\u016f: Amid Hydrolase mastn\u00fdch kyselin (FAAH) pro AEA a MonoAcylGlycerolLip\u00e1za (MAGL) pro 2-AG.<\/strong>\u00a0Klinick\u00fd syndrom nedostatku ECS (Russo) p\u0159i nedostate\u010dn\u00e9 produkci endokanabinoid\u016f nebo kanabinoidn\u00edch receptor\u016f by mohl b\u00fdt p\u0159\u00ed\u010dinou mnoha patologi\u00ed:<\/p>\r\n<ul>\r\n<li>p\u0159ecitliv\u011blost na bolest<\/li>\r\n<li>bolest hlavy<\/li>\r\n<li>migr\u00e9na<\/li>\r\n<li>syndrom podr\u00e1\u017ed\u011bn\u00e9ho st\u0159eva<\/li>\r\n<li>fibromyalgie<\/li>\r\n<li>deprese<\/li>\r\n<\/ul>\r\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-3.png\"><img loading=\"lazy\" decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-3.png\" class=\"aligncenter size-full wp-image-16224 lazyload\" alt=\"\" width=\"768\" height=\"432\"><noscript><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-16224\" src=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-3.png\" alt=\"\" width=\"768\" height=\"432\" srcset=\"https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-3.png 768w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-3-600x338.png 600w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-3-724x407.png 724w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-3-300x169.png 300w, https:\/\/www.alpha-cat.org\/wp-content\/uploads\/2019\/05\/French-doctor-explains-us-endo-cannabinoid-system-3-500x281.png 500w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><\/noscript><\/a><\/p>\r\n<p><strong>Dopln\u011bn\u00ed fytokanabinoidy m\u016f\u017ee tento nedostatek zlep\u0161it a zm\u00edrnit p\u0159\u00edznaky.<\/strong> Fytokanabinoidy interaguj\u00ed v ECS: THC aktivuje CB1R a vytv\u00e1\u0159\u00ed psychoaktivitu; CBD interaguje na mnoha receptorech (5-HT, GPR55, TRPV1\u2026) na mozkov\u00e9 \u00farovni p\u0159i \u00fazkosti, epilepsii, nauze\u00e1ln\u00ed spasticit\u011b, zvy\u0161uje hladinu AEA, roz\u0161i\u0159uje a sni\u017euje psychoaktivitu THC\u2026. <strong>ECS lze stimulovat n\u00e1sledovn\u011b:<\/strong><\/p>\r\n<ul>\r\n<li>po cvi\u010den\u00ed: aerobic, intenzivn\u00ed sport (vysok\u00e1 euforie b\u011b\u017ec\u016f), dechov\u00e1 cvi\u010den\u00ed, j\u00f3ga, meditace, akupunktura, ve\u0161ker\u00e9 pot\u011b\u0161en\u00ed a p\u0159\u00edjemn\u00e9 fyzick\u00e9 aktivity<\/li>\r\n<li>dieta bohat\u00e1 na omega-3, \u010dern\u00e1 \u010dokol\u00e1da, kurkuma, \u010dajov\u00e9 bylinn\u00e9 \u010daje (Echinacea), \u010dern\u00fd pep\u0159 (\u03b2 karyofylen terpen), ho\u0159\u010d\u00edk<\/li>\r\n<\/ul>\r\n<p><strong>Receptory ECS mohou b\u00fdt po\u0161kozeny pesticidy, ftal\u00e1ty \u010di alkoholem.<\/strong> ECS m\u00e1 <strong>p\u0159evahu<\/strong> nad r\u016fzn\u00fdmi biologick\u00fdmi procesy, v\u010detn\u011b imunitn\u00edch a mozkov\u00fdch syst\u00e9m\u016f, kter\u00e9 <strong>chr\u00e1n\u00ed<\/strong> organismus; Porozum\u011bn\u00ed <strong>ECS<\/strong> umo\u017en\u00ed prevenci a <strong>l\u00e9\u010dbu mnoho\u010detn\u00fdch nemoc\u00ed, jejich\u017e l\u00e9\u010dba m\u00e1 ve skute\u010dnosti mnoho vedlej\u0161\u00edch \u00fa\u010dink\u016f, m\u00e1lo relaps\u016f a l\u00e9ky na n\u011b jsou vz\u00e1cn\u00e9.<\/strong> Manipulace s <strong>ECS<\/strong> (nap\u0159. inhibic\u00ed degraduj\u00edc\u00edch enzym\u016f) nab\u00eddnou <strong>obrovsk\u00e9 terapeutick\u00e9 p\u0159\u00edle\u017eitosti pro t\u00e9m\u011b\u0159 v\u0161echny nemoci lid\u00ed v\u0161ech v\u011bkov\u00fdch skupin pro n\u00e1sleduj\u00edc\u00ed: bolest, \u00fazkost, deprese, stres, neurodegenerativn\u00ed patologie, epilepsie, rakovina\u2026<\/strong> \u010cl\u00e1nek je napsan\u00fd <strong>Dr. Janine GASTON-NHAN<\/strong>. \u010cl\u00e1nek je form\u00e1tovan\u00fd a publikovan\u00fd od <a href=\"https:\/\/www.alpha-cat.org\/\">Alpha-Cat<\/a>.<\/p>\r\n<p id=\"tw-target-text\" class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traduction\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Endokanabinoidn\u00ed syst\u00e9m (ECS) byl objeven asi p\u0159ed dvaceti lety po objevu \u03949 tetrahydrokanabinolu (THC), jeho synt\u00e9ze a specifick\u00e9m zp\u016fsobu&#8230;<\/p>\n","protected":false},"author":2271,"featured_media":16098,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","ocean_front_end_style_editor":"no","ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","osh_disable_topbar_sticky":"default","osh_disable_header_sticky":"default","osh_sticky_header_style":"default","osh_sticky_header_effect":"","osh_custom_sticky_logo":0,"osh_custom_retina_sticky_logo":0,"osh_custom_sticky_logo_height":0,"osh_background_color":"","osh_links_color":"","osh_links_hover_color":"","osh_links_active_color":"","osh_links_bg_color":"","osh_links_hover_bg_color":"","osh_links_active_bg_color":"","osh_menu_social_links_color":"","osh_menu_social_hover_links_color":"","ocean_post_oembed":"","ocean_post_self_hosted_media":"","ocean_post_video_embed":"","ocean_link_format":"","ocean_link_format_target":"self","ocean_quote_format":"","ocean_quote_format_link":"post","ocean_gallery_link_images":"on","ocean_gallery_id":[],"footnotes":""},"categories":[260],"tags":[],"class_list":["post-27998","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-cs","entry","has-media","owp-thumbs-layout-horizontal","owp-btn-big","owp-tabs-layout-horizontal","has-no-thumbnails"],"modified_by":"Mike","_links":{"self":[{"href":"https:\/\/www.alpha-cat.org\/cs\/wp-json\/wp\/v2\/posts\/27998","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.alpha-cat.org\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alpha-cat.org\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alpha-cat.org\/cs\/wp-json\/wp\/v2\/users\/2271"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alpha-cat.org\/cs\/wp-json\/wp\/v2\/comments?post=27998"}],"version-history":[{"count":0,"href":"https:\/\/www.alpha-cat.org\/cs\/wp-json\/wp\/v2\/posts\/27998\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.alpha-cat.org\/cs\/wp-json\/wp\/v2\/media\/16098"}],"wp:attachment":[{"href":"https:\/\/www.alpha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